Degree in Medicine and Surgery, University of Rome “La Sapienza” cum laude.

Specialization in Allergy and Clinical Immunology, Rome “La Sapienza” cum laude.

Research fellow at the Department of Immunology, Institute of Child Health, London (1978-81).

H.Clinical Assistant at the Hospital for Sick Children, London (1979-81).

Assistant Professor at the Faculty of Medicine and Surgery of the Università di L’Aquila (1983-84)
Assistant Professor, tenure, at the 3rd Institute of Clinical Medicine, then (1987) Department of Clinical Medicine of the 1st Faculty of Medicine and Surgery of the Università “La Sapienza” of Rome (1984-1999);
Research and study leave at the University of Modena and R. Emilia (1993).

Associate Professor of Internal Medicine at the Faculty of Medicine and Surgery of the Università “G. d’Annunzio” of Chieti-Pescara (1999-2004). Member of the board of the Department of Medicine and Sciences of Aging.
Full Professor of Internal Medicine at the Università “G. d’Annunzio” of Chieti-Pescara (2004-2021), teaching Clinical immunology, rheumatology, Emergency medicine, Medical Semeiotics for students of Medicine, Nursing, Fisiotherapy, and 12 Schools of specialization.

Sabbatical leave at the Miller School of Medicine, University of Miami, FL (2017).

Director of the School of Specialty in Rheumatology (2009-2014) of the Università “G. d’Annunzio” of Chieti-Pescara.

Director of the School of Specialty in Allergy and Clinical Immunology (2017-2021) of the University “G. d’Annunzio” of Chieti.

Member of the Council of the Italian Society of Allergy and Clinical Immunology – SIAIC (then Allergy, Asthma and Clinical Immunology – SIAAIC) four times, for 11 years.

Member of the Committee on Primary Immunodeficiencies of the World Allergy Organization (WAO).
Speaker and Moderator invited at several International Congresses in European countries, USA, Canada, Argentina, Venezuela, Japan, Turkey, Morocco, China.

Author/Co-author of more than 300 published papers, 250 in peer reviewed journals.

Academic Editor of Pathogens, section Vaccines and Therapeutic Developments; Associate Editor Frontiers in Pharmacology, section Translational Pharmacology Associate Editor Frontiers in Immunology, section Autoimmune and autoinflammatory Diseases.

Asociate Editor Immunity and Ageing and Co-Editor, topic Neuroimmunology and ageing.

Main Research interests:
Allergic diseases, mainly pathogenesis of food allergy, in vitro diagnostic tests, IgE regulation, allergenic molecules, urticarial, atopic dermatitis, mediators.

Primary immunodeficiencies, mainly immunoglobulin deficiencies, ataxia-telangectasia, T cell defects and SCID, diagnosis, immunological aspects and therapy with immunoglobulins (i.v. and s.c.);
Immunological aspects of HIV and other viral diseases, host correlates of susceptibility and resistance, immunological response to treatment (HAART and LTnP); Response to vaccination (immunocompromised and elderly subjects).

Rheumatic diseases, including SLE, rheumatoid arthritis, spondiloarthropathies, tendinitis.
Immunosenescence, changes of lymphocyte subsets and cytokine levels in normal aging and in age-associated diseases.

Pathomechanisms, antibodies, IgE and IgG subclasses, immune complexes, autoantibodies, cytokines and chemokines, other soluble mediators, cell-mediated immunity, biomarkers for diseases and pathological processes.